:root {
  color-scheme: light;
  --bg: #f7f9fc;
  --surface: #ffffff;
  --surface-alt: #eef4fb;
  --ink: #13233a;
  --muted: #5d6b7c;
  --line: #dce6f1;
  --blue: #0b4fb3;
  --blue-strong: #073b86;
  --cyan: #12a7b4;
  --green: #5c9f41;
  --shadow: 0 22px 58px rgba(19, 35, 58, 0.10);
  --max: 1180px;
}

html[data-theme="dark"] {
  color-scheme: dark;
  --bg: #07111f;
  --surface: #0d1b2d;
  --surface-alt: #10243d;
  --ink: #f5f8fc;
  --muted: #a9b7c7;
  --line: rgba(245, 248, 252, 0.14);
  --blue: #6aa8ff;
  --blue-strong: #9cc5ff;
  --cyan: #32c7d5;
  --green: #b7df7a;
  --shadow: 0 24px 68px rgba(0, 0, 0, 0.34);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: Inter, "SF Pro Display", "SF Pro Text", ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei", sans-serif;
  letter-spacing: 0;
  text-rendering: geometricPrecision;
}

a { color: inherit; text-decoration: none; }
button { font: inherit; }
img { max-width: 100%; }

.site-header { position: sticky; top: 0; z-index: 50; background: color-mix(in srgb, var(--surface) 94%, transparent); border-bottom: 1px solid var(--line); backdrop-filter: blur(16px); }
.utility-bar { min-height: 34px; display: flex; justify-content: flex-end; gap: 24px; align-items: center; width: min(var(--max), calc(100% - 44px)); margin: 0 auto; color: var(--muted); font-size: 12px; font-weight: 700; }
.main-nav { min-height: 72px; display: grid; grid-template-columns: minmax(250px, 1fr) auto minmax(280px, 1fr); align-items: center; gap: 22px; width: min(var(--max), calc(100% - 44px)); margin: 0 auto; }
.brand { display: flex; align-items: center; gap: 12px; min-width: 0; }
.brand img { width: 44px; height: 44px; border-radius: 10px; box-shadow: 0 10px 24px rgba(11,79,179,.14); }
.brand span { display: grid; gap: 2px; min-width: 0; }
.brand strong { overflow: hidden; color: var(--ink); font-size: 16px; line-height: 1.15; text-overflow: ellipsis; white-space: nowrap; }
.brand small { color: var(--muted); font-size: 12px; font-weight: 700; }
.nav-links { display: flex; align-items: center; justify-content: center; gap: 30px; color: var(--ink); font-size: 14px; font-weight: 760; }
.nav-links a { padding: 8px 0; border-bottom: 2px solid transparent; }
.nav-links a:hover { color: var(--blue); border-bottom-color: var(--blue); }
.header-actions { display: flex; justify-content: flex-end; align-items: center; gap: 10px; }
.toggle { display: inline-grid; grid-template-columns: repeat(2, minmax(36px, auto)); gap: 3px; min-height: 38px; padding: 3px; border: 1px solid var(--line); border-radius: 999px; background: var(--surface-alt); color: var(--muted); cursor: pointer; }
.toggle span { display: grid; place-items: center; min-width: 36px; padding: 0 8px; border-radius: 999px; font-size: 12px; font-weight: 800; }
.toggle span.active { background: var(--blue); color: #fff; }
.toggle.theme span { min-width: 50px; }
.header-cta, .button { min-height: 44px; display: inline-flex; align-items: center; justify-content: center; padding: 0 18px; border-radius: 4px; font-size: 14px; font-weight: 800; white-space: nowrap; }
.header-cta, .button.primary { background: var(--blue); color: #fff; border: 1px solid var(--blue); }
.button.secondary { background: color-mix(in srgb, var(--surface) 86%, transparent); color: var(--blue-strong); border: 1px solid color-mix(in srgb, var(--blue) 34%, var(--line)); }

.hero { position: relative; min-height: min(760px, calc(100svh - 106px)); display: grid; align-items: center; overflow: hidden; }
.hero-media { position: absolute; inset: 0; }
.hero-media img { width: 100%; height: 100%; object-fit: cover; object-position: 62% 50%; display: block; filter: saturate(1.02) contrast(1.02); }
.hero-overlay { position: absolute; inset: 0; background: linear-gradient(90deg, rgba(247,249,252,.98) 0%, rgba(247,249,252,.92) 34%, rgba(247,249,252,.42) 62%, rgba(247,249,252,.08) 100%); }
html[data-theme="dark"] .hero-overlay { background: linear-gradient(90deg, rgba(7,17,31,.96) 0%, rgba(7,17,31,.86) 36%, rgba(7,17,31,.42) 66%, rgba(7,17,31,.12) 100%); }
.hero-content { position: relative; z-index: 1; width: min(620px, calc(100% - 44px)); margin-left: max(22px, calc((100vw - var(--max)) / 2)); padding: 72px 0; }
.eyebrow { display: inline-flex; margin: 0 0 18px; color: var(--blue); font-size: 12px; font-weight: 850; letter-spacing: .09em; text-transform: uppercase; }
h1, h2, h3, p { margin-top: 0; }
h1 { margin-bottom: 20px; color: var(--ink); font-size: clamp(48px, 5.4vw, 76px); line-height: 1.02; letter-spacing: 0; font-weight: 820; }
.hero-content p:not(.eyebrow) { margin: 0; max-width: 560px; color: color-mix(in srgb, var(--ink) 76%, var(--muted)); font-size: 19px; line-height: 1.68; }
.hero-actions { display: flex; flex-wrap: wrap; gap: 12px; margin-top: 30px; }

.quick-links { position: relative; z-index: 2; width: min(var(--max), calc(100% - 44px)); margin: -54px auto 0; display: grid; grid-template-columns: repeat(4, minmax(0,1fr)); box-shadow: var(--shadow); }
.quick-links a { min-height: 126px; padding: 20px; border-right: 1px solid var(--line); background: var(--surface); }
.quick-links a:last-child { border-right: 0; }
.quick-links span { display: block; color: var(--blue); font-size: 12px; font-weight: 850; letter-spacing: .06em; text-transform: uppercase; }
.quick-links strong { display: block; margin-top: 20px; color: var(--ink); font-size: 20px; line-height: 1.25; }

.section, .feature-band, .contact-section { width: min(var(--max), calc(100% - 44px)); margin: 0 auto; padding: clamp(70px, 9vw, 118px) 0; border-bottom: 1px solid var(--line); }
.section-head { max-width: 850px; margin-bottom: 34px; }
.split-head { display: grid; grid-template-columns: minmax(0,1fr) minmax(340px,.8fr); gap: 48px; max-width: none; align-items: end; }
h2 { margin: 0 0 16px; color: var(--ink); font-size: clamp(34px, 4.6vw, 62px); line-height: 1.06; letter-spacing: 0; font-weight: 780; }
.section-head p, .feature-copy p, .focus-copy p, .contact-section p { color: color-mix(in srgb, var(--ink) 68%, var(--muted)); font-size: 17px; line-height: 1.68; }

.science-grid, .program-details, .focus-list, .team-grid { display: grid; gap: 16px; }
.science-grid { grid-template-columns: repeat(3, minmax(0,1fr)); }
.science-grid article, .program-details article, .focus-list article, .team-grid article, .program-name, .contact-card { background: var(--surface); border: 1px solid var(--line); box-shadow: var(--shadow); }
.science-grid article { min-height: 260px; padding: 26px; }
.science-grid h3 { margin: 74px 0 14px; color: var(--blue-strong); font-size: 24px; line-height: 1.15; }
.science-grid p, .program-details p, .focus-list p { color: color-mix(in srgb, var(--ink) 68%, var(--muted)); font-size: 15px; line-height: 1.62; }

.feature-band { display: grid; grid-template-columns: minmax(0,.82fr) minmax(420px,1fr); gap: clamp(32px, 6vw, 84px); align-items: center; }
.platform-steps { display: grid; grid-template-columns: repeat(2, minmax(0,1fr)); gap: 12px; }
.platform-steps div { min-height: 138px; padding: 22px; background: var(--surface); border: 1px solid var(--line); box-shadow: var(--shadow); }
.platform-steps span { color: var(--blue); font-size: 12px; font-weight: 850; letter-spacing: .08em; }
.platform-steps strong { display: block; margin-top: 34px; color: var(--ink); font-size: 21px; line-height: 1.25; }

.program-panel { display: grid; grid-template-columns: minmax(260px,.42fr) minmax(0,1fr); gap: 16px; }
.program-name { padding: 28px; display: grid; align-content: center; min-height: 270px; background: linear-gradient(135deg, var(--blue), var(--blue-strong)); color: #fff; }
.program-name span { font-size: 12px; font-weight: 850; letter-spacing: .08em; text-transform: uppercase; opacity: .8; }
.program-name strong { margin-top: 12px; font-size: clamp(46px, 6vw, 76px); line-height: .95; }
.program-name small { margin-top: 12px; font-size: 16px; font-weight: 750; opacity: .9; }
.program-details { grid-template-columns: repeat(3, minmax(0,1fr)); }
.program-details article { padding: 22px; }
.program-details span, .focus-list span, .contact-card span { color: var(--blue); font-size: 12px; font-weight: 850; letter-spacing: .08em; text-transform: uppercase; }
.program-details p { margin-top: 40px; }

.focus-grid { display: grid; grid-template-columns: minmax(0,.72fr) minmax(420px,1fr); gap: clamp(32px, 6vw, 84px); align-items: start; }
.focus-list { grid-template-columns: 1fr; }
.focus-list article { min-height: 118px; padding: 22px; }
.focus-list p { margin: 18px 0 0; }

.team-grid { grid-template-columns: repeat(4, minmax(0,1fr)); }
.team-grid article { overflow: hidden; }
.team-grid img { width: 100%; aspect-ratio: 1 / 1.08; object-fit: cover; display: block; filter: saturate(1.02) contrast(1.02); }
.team-grid h3 { margin: 18px 16px 8px; color: var(--ink); font-size: 18px; line-height: 1.24; }
.team-grid p { margin: 0 16px 20px; color: var(--blue); font-size: 13px; font-weight: 820; }

.contact-section { display: grid; grid-template-columns: minmax(0,1fr) minmax(320px,420px); gap: 40px; align-items: center; }
.contact-card { display: grid; gap: 12px; padding: 24px; }
.contact-card strong { color: var(--ink); font-size: 21px; line-height: 1.35; }
.contact-card small { color: var(--blue); font-size: 16px; font-weight: 850; }
.site-footer { display: grid; grid-template-columns: minmax(220px,1fr) auto minmax(240px,1fr); gap: 24px; align-items: center; padding: 34px max(22px, calc((100vw - var(--max)) / 2)); background: var(--surface-alt); color: var(--muted); font-size: 13px; }
.site-footer div { display: grid; gap: 4px; color: var(--ink); }
.site-footer nav { display: flex; gap: 22px; color: var(--blue); font-weight: 760; }
.site-footer small { text-align: right; }

[data-reveal] { opacity: 0; transform: translateY(18px); transition: opacity 620ms ease, transform 620ms ease; }
[data-reveal].is-visible { opacity: 1; transform: translateY(0); }

@media (max-width: 1120px) {
  .main-nav { grid-template-columns: minmax(220px,1fr) auto; }
  .nav-links { display: none; }
  .quick-links { grid-template-columns: repeat(2, minmax(0,1fr)); }
  .quick-links a:nth-child(2) { border-right: 0; }
  .quick-links a:nth-child(-n+2) { border-bottom: 1px solid var(--line); }
  .science-grid, .program-panel, .feature-band, .focus-grid, .contact-section, .split-head { grid-template-columns: 1fr; }
  .program-details, .team-grid { grid-template-columns: repeat(2, minmax(0,1fr)); }
}

@media (max-width: 720px) {
  .utility-bar { display: none; }
  .main-nav { width: min(100% - 28px, var(--max)); grid-template-columns: 1fr; gap: 10px; padding: 12px 0; }
  .header-actions { justify-content: flex-start; flex-wrap: wrap; }
  .header-cta { display: none; }
  .hero { min-height: 690px; align-items: end; }
  .hero-media img { object-position: 70% 50%; }
  .hero-overlay { background: linear-gradient(180deg, rgba(247,249,252,.22) 0%, rgba(247,249,252,.86) 42%, rgba(247,249,252,.99) 100%); }
  html[data-theme="dark"] .hero-overlay { background: linear-gradient(180deg, rgba(7,17,31,.20) 0%, rgba(7,17,31,.82) 42%, rgba(7,17,31,.99) 100%); }
  .hero-content { width: min(100% - 28px, var(--max)); margin: 0 auto; padding: 0 0 44px; }
  h1 { font-size: clamp(38px, 10vw, 50px); line-height: 1.06; }
  .hero-content p:not(.eyebrow) { font-size: 16px; line-height: 1.58; }
  .quick-links, .section, .feature-band, .contact-section { width: min(100% - 28px, var(--max)); }
  .quick-links { margin-top: 0; grid-template-columns: 1fr; }
  .quick-links a { min-height: 94px; border-right: 0; border-bottom: 1px solid var(--line); }
  .quick-links a:last-child { border-bottom: 0; }
  h2 { font-size: clamp(30px, 8.4vw, 42px); line-height: 1.08; }
  .section, .feature-band, .contact-section { padding: 64px 0; }
  .science-grid, .program-details, .team-grid, .platform-steps { grid-template-columns: 1fr; }
  .science-grid article { min-height: auto; }
  .science-grid h3 { margin-top: 44px; }
  .program-name { min-height: 210px; }
  .site-footer { grid-template-columns: 1fr; padding: 28px 14px; }
  .site-footer nav { flex-wrap: wrap; }
  .site-footer small { text-align: left; }
}

.brand img {
  width: 226px;
  height: auto;
  border-radius: 0;
  box-shadow: none;
  display: block;
}

html[data-theme="dark"] .brand img {
  filter: brightness(1.28) saturate(0.92);
}

@media (max-width: 720px) {
  .brand img {
    width: 198px;
  }
}

.footer-brand img {
  width: 214px;
  height: auto;
  display: block;
}

html[data-theme="dark"] .footer-brand img {
  filter: brightness(1.25) saturate(0.94);
}

@media (max-width: 720px) {
  .footer-brand img {
    width: 190px;
  }
}

/* Pfizer-inspired visual content upgrade */
.quick-links {
  overflow: hidden;
  border: 1px solid var(--line);
  background: var(--surface);
}

.quick-links a {
  min-height: 238px;
  display: grid;
  grid-template-rows: 132px 1fr;
  padding: 0;
  overflow: hidden;
  transition: transform 220ms ease, box-shadow 220ms ease, background 220ms ease;
}

.quick-links a:hover {
  z-index: 3;
  transform: translateY(-3px);
  box-shadow: 0 22px 48px rgba(11, 79, 179, .14);
}

.quick-links img {
  width: 100%;
  height: 132px;
  display: block;
  object-fit: cover;
  filter: saturate(1.04) contrast(1.02);
}

.quick-copy {
  display: grid;
  align-content: start;
  padding: 18px 20px 20px;
}

.quick-links strong {
  margin-top: 16px;
}

.section-head {
  max-width: 780px;
}

.science-grid article {
  min-height: auto;
  display: grid;
  grid-template-rows: 220px 1fr;
  padding: 0;
  overflow: hidden;
  border-radius: 8px;
}

.science-grid article > img {
  width: 100%;
  height: 220px;
  display: block;
  object-fit: cover;
}

.science-card-copy {
  padding: 24px;
}

.science-grid h3 {
  margin: 0 0 12px;
}

.science-grid p,
.program-details p,
.focus-list p {
  margin-bottom: 0;
}

.feature-band {
  grid-template-columns: minmax(0, .72fr) minmax(500px, 1.08fr);
  align-items: stretch;
}

.platform-visual {
  position: relative;
  min-height: 520px;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--surface);
  box-shadow: var(--shadow);
}

.platform-visual > img {
  width: 100%;
  height: 100%;
  min-height: 520px;
  display: block;
  object-fit: cover;
}

.platform-visual::after {
  content: "";
  position: absolute;
  inset: 0;
  background: linear-gradient(180deg, rgba(7, 17, 31, .02), rgba(7, 17, 31, .64));
  pointer-events: none;
}

.platform-badge {
  position: absolute;
  top: 20px;
  left: 20px;
  z-index: 2;
  display: grid;
  gap: 7px;
  max-width: 270px;
  padding: 16px 18px;
  border: 1px solid rgba(255,255,255,.38);
  border-radius: 8px;
  background: rgba(255,255,255,.82);
  color: #13233a;
  backdrop-filter: blur(16px);
}

.platform-badge span {
  color: #0b4fb3;
  font-size: 11px;
  font-weight: 850;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.platform-badge strong {
  font-size: 22px;
  line-height: 1.14;
}

.platform-steps {
  position: absolute;
  left: 20px;
  right: 20px;
  bottom: 20px;
  z-index: 2;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 10px;
}

.platform-steps div {
  min-height: 112px;
  padding: 16px;
  border-color: rgba(255,255,255,.34);
  border-radius: 8px;
  background: rgba(255,255,255,.86);
  box-shadow: none;
  backdrop-filter: blur(16px);
}

html[data-theme="dark"] .platform-steps div,
html[data-theme="dark"] .platform-badge {
  background: rgba(13, 27, 45, .78);
  color: #f5f8fc;
}

.platform-steps strong {
  margin-top: 14px;
  font-size: 15px;
  line-height: 1.28;
}

.program-panel {
  grid-template-columns: minmax(220px, .34fr) minmax(300px, .78fr) minmax(280px, .48fr);
  align-items: stretch;
}

.program-name {
  border-radius: 8px;
}

.program-image {
  min-height: 330px;
  margin: 0;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--surface);
  box-shadow: var(--shadow);
}

.program-image img {
  width: 100%;
  height: 100%;
  min-height: 330px;
  display: block;
  object-fit: cover;
}

.program-details {
  grid-template-columns: 1fr;
}

.program-details article {
  border-radius: 8px;
}

.program-details p {
  margin-top: 18px;
}

.focus-grid {
  grid-template-columns: minmax(240px, .55fr) minmax(330px, .74fr) minmax(280px, .58fr);
  align-items: stretch;
  gap: 16px;
}

.focus-media {
  min-height: 360px;
  margin: 0;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: var(--surface);
  box-shadow: var(--shadow);
}

.focus-media img {
  width: 100%;
  height: 100%;
  display: block;
  object-fit: cover;
}

.focus-list article {
  border-radius: 8px;
}

.contact-card {
  border-radius: 8px;
  background: linear-gradient(135deg, var(--surface), color-mix(in srgb, var(--blue) 9%, var(--surface)));
}

.email-link {
  color: var(--blue-strong);
  font-size: clamp(25px, 2.6vw, 38px);
  font-weight: 850;
  line-height: 1.08;
  word-break: break-word;
}

.contact-card small {
  color: color-mix(in srgb, var(--ink) 68%, var(--muted));
}

@media (max-width: 1120px) {
  .quick-links {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .quick-links a:nth-child(2) {
    border-right: 0;
  }

  .quick-links a:nth-child(-n+2) {
    border-bottom: 1px solid var(--line);
  }

  .feature-band,
  .program-panel,
  .focus-grid {
    grid-template-columns: 1fr;
  }

  .program-details {
    grid-template-columns: repeat(3, minmax(0, 1fr));
  }

  .focus-media {
    min-height: 420px;
  }
}

@media (max-width: 720px) {
  .quick-links {
    grid-template-columns: 1fr;
  }

  .quick-links a {
    min-height: 212px;
    grid-template-rows: 116px 1fr;
    border-right: 0;
    border-bottom: 1px solid var(--line);
  }

  .quick-links img {
    height: 116px;
  }

  .quick-copy {
    padding: 16px;
  }

  .science-grid article {
    grid-template-rows: 190px auto;
  }

  .science-grid article > img {
    height: 190px;
  }

  .science-card-copy {
    padding: 20px;
  }

  .platform-visual {
    min-height: auto;
    display: grid;
  }

  .platform-visual > img {
    height: 260px;
    min-height: 260px;
  }

  .platform-visual::after {
    background: linear-gradient(180deg, rgba(7, 17, 31, .08), rgba(7, 17, 31, .48));
  }

  .platform-badge {
    top: 14px;
    left: 14px;
    right: 14px;
    max-width: none;
    padding: 13px 14px;
  }

  .platform-steps {
    position: relative;
    left: auto;
    right: auto;
    bottom: auto;
    grid-template-columns: 1fr;
    padding: 14px;
    background: var(--surface);
  }

  .platform-steps div {
    min-height: 82px;
    background: var(--surface-alt);
    border-color: var(--line);
  }

  .program-image,
  .program-image img {
    min-height: 260px;
  }

  .program-details {
    grid-template-columns: 1fr;
  }

  .focus-media {
    min-height: 260px;
  }
}